| Correct electrolyte disturbances before Rx. Hepatic and Renal insufficiency, COPD, Patients on Cardiac pacemaker, Patients with less than 70 kg of body weightPromethazine should be used with extreme caution in patients who have bladder or GI obstruction, prostatic hypertrophy, urinary retention, narrow- angle glaucoma, CVS disease or hepatic impairment |