Acetaminophen: May reduce lamotrigine levels. Monitor lamotrigine levels.
Carbamazepine,phenobarbital, phenytoin, primidone. Decreased lamotrigine steady-state levels. Monitor child closely.
Folate inhibitors (such as co-trimoxazole, methotrexate): Possible additive effects. Monitor child closely.
Valproic acid: Decreased lamotrigine clearance, which increases drugs steady-state levels. Mon-itor child closely for toxicity.
Drug-lifestyle. Sun exposure: Possible photosensitivity reactions. Tell child to take precautions. |