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| Dosages: | Partial seizures
Adolescent > 16 yr, adult: 50 mg PO qd × 2 wk ; then 100 mg qd in 2 divided doses × 2 wk. Maintenance 300-500 mg PO qd in 2 divided doses. Pt on valproic acid: 25 mg PO every other day × 2 wk; then 25 mg PO qd × 2 wk. Max 150 mg PO qd in 2 divided doses.
Lennox-Gastaut syndrome-Round doses down to nearest 5 mg.
Child 2-12 yr: 0.6 mg/kg PO qd in 2 divided doses × 2 wk, then 1.2 mg/kg PO qd in 2 divided doses. Increase q 1-2 wk by 1.2 mg/kg/day until maintenance 5-15 mg/kg/day (max 400 mg/day). Pt on valproic acid: 0.15 mg/kg PO qd in 1-2 divided doses × 2 wk. If initial dose 2.5-5 mg, give 5-mg dose on alternate day × 2 wk. For next 2 wk, 0.3 mg/kg PO qd in 1-2 divided doses. Increase q 1-2 wk by 0.3 mg/kg/day until maintenance 1-5 mg/kg/day (max 200 mg/day in 1-2 divided doses).
Child > 12 yr, adult: 50 mg PO qd × 2 wk, then 100 mg qd in 2 divided doses × 2 wk. Maintenance 300-500 mg PO qd in 2 divided doses. Pt on valproic acid: 25 mg PO every other day × 2 wk, then 25 mg PO qd × 2 wk. Maintenance 100-400 mg PO qd in 1-2 divided doses. |
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