Bacteriostatic drugs (chlorampheni-col, erythromycin, tetracyclines): May impair its bactericidal activity. Monitor patient for drug effect.
Loop diuretics, nephrotoxic drugs (aminoglyco-sides, colistin, polymyxin B, vancomycin): May increase risk of nephrotoxicity. Use together cautiously.
Probenecid. Competitively inhibits renal tubular secretion of cephalosporins, resulting in higher, prolonged serum levels of these drugs. Use with caution. |