Respiratory, GU, skin, soft-tissue, bone, joint infection; biliary tract infection; septicemia, endocarditis
Neonate = 1 wk: 40 mg/kg IM or IV qd in divided doses q 12 h.
Neonate > 1 wk and < 2 kg: 40 mg/kg IM or IV qd in divided doses q 12 h.
Neonate > 1 wk and > 2 kg: 60 mg/kg IM or IV qd in divided doses q 8 h.
Infant, child > 1 month: 25-100 mg/kg/day IM or IV in divided doses q 6-8 h.
Adolescent, adult: 250 mg IM or IV q 8 h-1.5 gram q 6 h. Max 12 gram/day in lifethreatening infection.
Perioperative prophylaxis
Adolescent, adult: 1 gram IM or IV 30-60 min before surgery; then 0.5-1 gram IM or IV q 6-8 h × 24 h. In surgery > 2 h, another 0.5-1 gram IM or IV may be given. |