Amphotericin B, diuretics: May en-hance hypokalemia.
Monitor potassium levels. Antacids, cholestyramine, coleshpol: Decreased effect of betamethasone by adsorbing the corti-costeroid, decreasing the amount absorbed. Avoid using together.
Barbiturates, phenytoin, rifampin: May cause de-creased corticosteroid effects. Use cautiously; monitor patient.
Cardiac glycosides: Increased risk of toxicity from hypokalemia. Monitor potassium levels.
Estrogens: May reduce metabolism of cortico-steroids by increasing transcortin levels. Half-life of the corticosteroid is then prolonged because of increased protein-binding. Use with caution.
Insulin, oral antidiabetics: May cause hypergly-cemia.
Dosage adjustment may be needed. Isoniazid, salicylates: Increased metabolism of isoniazid and salicylates. Monitor patient for ef-fects.
Oral anticoagulants: May decrease effects of oral anticoagulants (rarely). Monitor patient for effects.
Ulcerogenic drugs such as NSAIDs: May increase risk of GI ulceration. Avoid concomitant use. |