| Contraindicated in children with hypersensitivity to drug and in those with history of aspirinor NSAID-induced asthma, rhinitis, or urticaria; in pregnancy, or while breast-feeding. Also contra-indicated in infants with untreated infection, ac-tive bleeding, coagulation defects or thrombocy-topenia, congenital heart disease in those for whom patency of the ductus arteriosus is nec-essary for satisfactory pulmonary or systemic blood flow, necrotizing enterocolitis, or impaired renal function. Suppositories are contraindicated in children with a history of proctitis or recent rectal bleeding. |