Calcium channel blockers (verapamil, possibly diltiazem):
May increase serum levels of carbamazepine significantly; decrease carba-mazepine dosage by 40% to 50% when given with verapamil.
Cimetidine, clarithromycin, erythromycin, isoni-azid, propoxyphene, valproic acid:
May increase serum carbamazepine levels. Use cautiously; monitor carbamazepine levels.
Ethosuximide, haloperidol, phenytoin, valproic acid, warfarin:
Carbamazepine may increase me-tabolism of these drugs. Monitor patient care-fully.
Felbamate:
Concomitant use may result in low-er serum levels of either drug. Monitorpatient and drug levels.
Fluoxetine, fluvoxamine.
May increase carba-mazepine levels. Monitor carbamazepine levels.
MAO inhibitors:
Concomitant use may cause hy-pertensive crisis. Avoid concomitant use or use drug within 14 days of MAOs.
Oral contraceptives, theophylline:
Carbamazepine may decrease effectiveness of these drugs. Mon-itor patient; suggest alternate method of contra-ception.
Phenobarbital, phenytoin, primidone:
Lowers serum carbamazepine levels. Monitor serum car-bamazepine level. |