Seizures
Child < 6 yr: 10-20 mg/kg PO qd in 2-3 divided doses as tab or 4 divided doses as susp. Increase q wk to max 35 mg/kg/24 h.
Child 6-12 yr: 100 mg PO bid as tab or 50 mg PO qid as susp. Increase q wk by 100 mg PO qd, tid-qid. Max 1,000 mg/day. Child taking = 400 mg immed-rel qd may be given extended-release caps bid.
Child > 12 yr, adult: 200 mg PO bid as tab or 100 mg PO qid as susp on day 1. Increase by 200 mg/day PO q wk in divided doses 6-8 h. Adjust to minimum effective level when control achieved. Max 1,000 mg/day in child 13-15 yr, or 1,200 mg/day in child > 15 yr. Doses up to 1,600 mg/day have been used in adult. For extended-release caps, 200 mg PO bid. Increase q wk by up to 200 mg/day until response. For extended-release tab, 100-200 mg PO qd or bid with meals. Increase q wk by 100 mg/day until response. For extended-release caps and tab, max 1,000 mg/day in child 12-15 yr and 1,200 mg/day in pts > 15 yr. Adult max 1,600 mg/day Maintenance 800-1200 mg/day.
Loading dose for rapid seizure control
Child < 12 yr: 10 mg/kg oral susp in 1 dose.
Child = 12 yr, adult: 8 mg/kg oral susp in 1 dose. |