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| Interactions: | Itraconazole
Adverse Effect: loss of itraconazole efficacy Clinical Management: Itraconazole should be administered with a cola beverage if the patient is receiving an H2 receptor antagonist, such as roxatidine.
Ketoconazole
Adverse Effect: loss of ketoconazole efficacy Clinical Management: Concurrent administration of ketoconazole and roxatidine is not recommended. If concurrent use cannot be avoided, roxatidine should be taken at least two hours after ketoconazole. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antifungal efficacy. |
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