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Interactions: | AtenololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
BisoprololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
CarvedilolAdverse Effect: Hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
CelecoxibAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
CeliprololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
ChloramphenicolAdverse Effect: hypoglycemiaClinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).
Diclofenac Preps.Adverse Effect: A possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
FlurbiprofenAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
IbuprofenAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
IndomethacinAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
KetoprofenAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
KetorolacAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
LabetalolAdverse Effect: Hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Mefenamic AcidAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
MeloxicamAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
MetoprololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
MiconazoleAdverse Effect: severe hypoglycemiaClinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).
NabumetoneAdverse Effect: A possible increased risk of hypoglycemiaClinical Management: When Nabumetone is coadministered with Glimepiride , patients should be monitored more closely for hypoglycemia. Dose of Glimepiride may need to be reduced when Nabumetone is added to therapy.
NaproxenAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
NimesulideAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
OxprenololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
OxyphenbutazoneAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
ParacetamolAdverse Effect: A possible increased risk of hypoglycemiaClinical Management: When Paracetamol is coadministered with Glimepiride , patients should be monitored more closely for hypoglycemia. Dose of Glimepiride may need to be reduced when Paracetamol is added to therapy.
PhenacetinAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
PhenylbutazoneAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
PindololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
PiroxicamAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
ProbenecidAdverse Effect: HypoglycemiaClinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).
PropranololAdverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
SelegilineAdverse Effect: excessive hypoglycemia, CNS depression, and seizuresClinical Management: Blood glucose levels should be closely monitored when Selegiline is added or discontinued in a patient receiving Glimepiride . Lower doses of hypoglycemic drugs may be required with concomitant therapy.
SulphadiazineAdverse Effect: enhanced hypoglycemic effectsClinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glimepiride . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
TenoxicamAdverse Effect: a possible increased risk of hypoglycemiaClinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy. |
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