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Glimepiride Drug Name:  
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Indications
Dosages
Interactions
Precautions
Contraindications
Adverse Reactions
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Interactions:

Atenolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Bisoprolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Carvedilol

  • Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Celecoxib

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Celiprolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Chloramphenicol

  • Adverse Effect: hypoglycemia
  • Clinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).

    Diclofenac Preps.

  • Adverse Effect: A possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Flurbiprofen

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Ibuprofen

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Indomethacin

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Ketoprofen

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Ketorolac

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Labetalol

  • Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Mefenamic Acid

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Meloxicam

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Metoprolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Miconazole

  • Adverse Effect: severe hypoglycemia
  • Clinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).

    Nabumetone

  • Adverse Effect: A possible increased risk of hypoglycemia
  • Clinical Management: When Nabumetone is coadministered with Glimepiride , patients should be monitored more closely for hypoglycemia. Dose of Glimepiride may need to be reduced when Nabumetone is added to therapy.

    Naproxen

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Nimesulide

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Oxprenolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Oxyphenbutazone

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Paracetamol

  • Adverse Effect: A possible increased risk of hypoglycemia
  • Clinical Management: When Paracetamol is coadministered with Glimepiride , patients should be monitored more closely for hypoglycemia. Dose of Glimepiride may need to be reduced when Paracetamol is added to therapy.

    Phenacetin

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Phenylbutazone

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.  

    Pindolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Piroxicam

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.

    Probenecid

  • Adverse Effect: Hypoglycemia
  • Clinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).

    Propranolol

  • Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
  • Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.

    Selegiline

  • Adverse Effect: excessive hypoglycemia, CNS depression, and seizures
  • Clinical Management: Blood glucose levels should be closely monitored when Selegiline is added or discontinued in a patient receiving Glimepiride . Lower doses of hypoglycemic drugs may be required with concomitant therapy.

    Sulphadiazine

  • Adverse Effect: enhanced hypoglycemic effects
  • Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glimepiride . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.

    Tenoxicam

  • Adverse Effect: a possible increased risk of hypoglycemia
  • Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
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