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Gentamicin Drug Name:  
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Adverse Reactions
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Interactions:

Amoxycillin

  • Adverse Effect: loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Amoxycillin + Bromhexine Comb.

  • Adverse Effect: Loss of aminoglycoside efficacy
  • Clinical Management: Monitor patients for aminoglycoside effectiveness.

    Amoxycillin + Carbocisteine Comb.

  • Adverse Effect: Loss of aminoglycoside efficacy
  • Clinical Management: Monitor patients for aminoglycoside effectiveness.

    Amoxycillin + Clavulanic Acid Comb.

  • Adverse Effect: Loss of aminoglycoside efficacy
  • Clinical Management: Monitor patients for aminoglycoside effectiveness.

    Amoxycillin + Cloxacillin Comb.

  • Adverse Effect: Loss of aminoglycoside efficacy
  • Clinical Management: Monitor patients for aminoglycoside effectiveness.

    Ampicillin

  • Adverse Effect: loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Atracurium

  • Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis
  • Clinical Management: Avoid concomitant use of Gentamicin and Atracurium if possible. Concurrent use of Gentamicin and Atracurium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.

    Bacampicillin

  • Adverse Effect: Loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Benzathine Penicillin

  • Adverse Effect: Loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Benzyl Penicillin

  • Adverse Effect: loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Bumetanide

  • Adverse Effect: ototoxicity
  • Clinical Management: Consider periodic auditory testing for patients with renal dysfunction, or for patients on high doses of either drug.

    Capreomycin

  • Adverse Effect: gentamicin toxicity (ototoxicity, nephrotoxicity)
  • Clinical Management: If concomitant administration is necessary, respiratory function, renal function and auditory function should be monitored closely.

    Carbenicillin

  • Adverse Effect: Loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Carboplatin

  • Adverse Effect: ototoxicity
  • Clinical Management: If clinically acceptable, an alternate antibiotic (a non-aminoglycoside) may be preferred.

    Cefaclor

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefaclor could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefadroxil

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefadroxil could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefazolin

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefazolin could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefixime

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefixime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefoperazone

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefotaxime

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefotaxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefpirome

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefpirome could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefpodoxime

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Ceftazidime

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Ceftazidime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Ceftizoxime

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Ceftizoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Ceftriaxone

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Ceftriaxone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cefuroxime

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cefuroxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cephalexin

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cephalexin could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cephaloridine

  • Adverse Effect: an increased risk of nephrotoxicity
  • Clinical Management: Coadministration of Gentamicin with Cephaloridine could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.

    Cloxacillin

  • Adverse Effect: Loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Cyclosporin

  • Adverse Effect: Nephrotoxicity
  • Clinical Management: Monitor for signs and symptoms of nephrotoxicity and administer the drug with caution.

    Frusemide

  • Adverse Effect: ototoxicity and/or nephrotoxicity
  • Clinical Management: Consider periodic auditory testing for patients on high doses of either drug. Also monitor renal function.

    Indomethacin

  • Adverse Effect: Gentamicin toxicity (renal dysfunction, ototoxicity)
  • Clinical Management: Monitor aminoglycoside levels closely for one to two days as well as renal function after starting or discontinuing indomethacin.

    Mg. salts

  • Adverse Effect: Neuromuscular weakness
  • Clinical Management: Monitor patients for respiratory dysfunction and apnea. If neuromuscular blockade occurs, discontinue Gentamicin and change antibiotic therapy. Patients receiving large cumulative dose of Gentamicin should have serum calcium, magnesium, potassium, and creatinine monitored.

    Pancuronium

  • Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis
  • Clinical Management: Avoid concomitant use of Gentamicin and Pancuronium if possible. Concurrent use of Gentamicin and Pancuronium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.

    Penicillin V ( Phenoxymethyl )

  • Adverse Effect: loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Pipecuronium

  • Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis
  • Clinical Management: Avoid concomitant use of Gentamicin and Pipecuronium if possible. Concurrent use of Gentamicin and Pipecuronium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.

    Piperacillin

  • Adverse Effect: Loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Procaine Penicillin

  • Adverse Effect: Loss of Gentamicin efficacy
  • Clinical Management: Monitor patients for Gentamicin effectiveness.

    Succinyl Choline

  • Adverse Effect: enhanced neuromuscular blockade
  • Clinical Management: Titrate the dose of Succinyl Choline carefully. Monitor patients not on a ventilator for respiratory paralysis.

    Vancomycin

  • Adverse Effect: nephrotoxicity
  • Clinical Management: Renal function tests should be closely monitored.

    Vecuronium

  • Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis
  • Clinical Management: Avoid concomitant use of Gentamicin and Vecuronium if possible. Concurrent use of Gentamicin and Vecuronium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.
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