| Contraindicated in patients with hypersensitivi(y to trimethoprim or sulfonamides, severe renal im-pairment (creatinine clearance below 15 ml/ minute), or porphyria; in those with megaloblas-tic anemia caused by folate deficiency; in preg-nant women at term; in breastfeeding women; and in children under 2 months.Use cautiously in children with impaired re-nal or hepatic function, severe allergies, severe bronchial asthma, G6PD deficiency, or blood dyscrasia. |