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| Interactions: | Drug-drug.
Allopurinol: Appears to increase risk of rash from both drugs. Monitor patient carefully.
Aminogtycoside antibiofc: Concomitant use caus-ps a synergistic bactericidal effect against some strains of enterococci and group B streptococci. Drugs are physically and chemically incompati-)le; inactivated it mixed or given together. Dont nix or give together.
Clavulanate: Results in increased bactericidal effects because clavulanic acid is betalactamase inhibitor. Used for this therapeutic purpose.
Methotrexate: Large doses of penicillins may interfere with renal tubular secretion of methotrex-ate, delaying elimination and elevating serum lev-sls of methotrexate. Monitor methotrexate levels.
Probenecid: Inhibits renal tubular secretion of ampicillin, raising its serum levels. Use as adjunct to antibiotic therapy. |
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