Systemic infection, UTI
Neonate = 1 wk and < 2 kg: 25 mg/kg IM or IV q 12 h.
Neonate = 1 wk and > 2 kg: 25 mg/kg IM or IV q 8 h.
Neonate > 1 wk and = 2 kg: 25 mg/kg IM or IV q 8 h.
Neonate > 1 week and > 2 kg: 25 mg/kg IM or IV q 6 h.
Child: 50-100 mg/kg PO, IV, or IM qd, in divided doses q 6 h for mild to moderate infection; or 200-400 mg/kg IM or IV qd, in divided doses q 4-6 h for severe infection.
Adult: 250-500 mg PO q 6 h.
Meningitis
Neonate = 1 wk and = 2 kg: 50-75 mg/kg IV q 12 h.
Neonate = 1 wk and > 2 kg: 50-75 mg/kg IV q 8 h.
Neonate > 1 wk and = 2 kg: 50 mg/kg IV q 8 h.
Neonate > 1 wk and > 2 kg: 50 mg/kg IV q 6 h.
Infant, child 2 month-12 yr:Up to 400 mg/kg IV qd × 3 day, then up to 300 mg/kg IM divided q 4 h.
Adult: 8-14 gram IV divided q 3-4 h × 3 day; then IM if desired.
Uncomplicated gonorrhea
Child < 40 kg: 50 mg/kg/day IV or IM in divided doses q 6-8 h.
Child > 40 kg, adult: 500 mg IV or IM q 6 h.
Adult: 3.5 gram PO with 1 gram probenecid in 1 dose.
Prophylaxis for bacterial endocarditis before dental or minor respiratory procedures
Child: 30 mg/kg IV or IM within 30 min of procedure.
Adult: 2 gram IV or IM within 30 min of procedure. |