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| Interactions: | Amoxycillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Ampicillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Atracurium
Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Clinical Management: Avoid concomitant use of Streptomycin and Atracurium if possible. Concurrent use of Streptomycin and Atracurium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.
Bacampicillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Benzathine Penicillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Benzyl Penicillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Bumetanide
Adverse Effect: An increased risk of ototoxicity (tinnitus, transient or permanent hearing loss, dizziness, vertigo) Clinical Management: Avoid using this combination in patients with renal impairment, inner ear dysfunction, and those receiving high doses of either drug. If possible, avoid giving long courses of this combination therapy. Before beginning treatment, determine that hearing and renal function are unimpaired and follow up with regular audiometric and renal function monitoring. Alternatively, consider switching to a non-loop diuretic or use of an antibiotic not associated with ototoxicity.
Capreomycin
Adverse Effect: streptomycin toxicity (ototoxicity, nephrotoxicity) Clinical Management: If concomitant administration is necessary, respiratory function, renal function and auditory function should be monitored closely.
Carbenicillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Carboplatin
Adverse Effect: ototoxicity Clinical Management: If clinically acceptable, an alternate antibiotic (a non-aminoglycoside) may be preferred.
Cefaclor
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefaclor could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefadroxil
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefadroxil could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefazolin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefazolin could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefixime
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefixime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefoperazone
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefotaxime
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefotaxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefpodoxime
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Ceftazidime
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Ceftazidime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Ceftizoxime
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Ceftizoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Ceftriaxone
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Ceftriaxone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cefuroxime
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefuroxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cephalexin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cephalexin could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cephaloridine
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cephaloridine could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Cloxacillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Frusemide
Adverse Effect: ototoxicity and/or nephrotoxicity Clinical Management: Consider periodic auditory testing for patients on high doses of either drug. Also monitor renal function.
Mg. salts
Adverse Effect: Neuromuscular weakness Clinical Management: Monitor patients for respiratory dysfunction and apnea. If neuromuscular blockade occurs, discontinue Streptomycin and change antibiotic therapy. Patients receiving large cumulative doses of aminoglycosides should have serum calcium, magnesium, potassium, and creatinine monitored.
Pancuronium
Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Clinical Management: Avoid concomitant use of Streptomycin and Pancuronium if possible. Concurrent use of Pancuronium and Streptomycin requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.
Penicillin V ( Phenoxymethyl )
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Pipecuronium
Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Clinical Management: Avoid concomitant use of Streptomycin and Pipecuronium if possible. Concurrent use of Streptomycin and Pipecuronium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status.
Piperacillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Procaine Penicillin
Adverse Effect: Loss of Streptomycin efficacy Clinical Management: Monitor patients for Streptomycin effectiveness.
Succinyl Choline
Adverse Effect: succinylcholine toxicity (respiratory depression) Clinical Management: Titrate the dose of the Succinyl Choline carefully. Monitor patients not on a ventilator for respiratory paralysis.
Vecuronium
Adverse Effect: enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Clinical Management: Avoid concomitant use of Streptomycin and Vecuronium if possible. Concurrent use of Streptomycin and Vecuronium requires close monitoring of the patients clinical condition, especially respiratory and oxygenation status. |
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