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| Interactions: | Aspirin
Adverse Effect: Increased rate of GI ulceration and other complications # Clinical Management: Avoid concomitant use if possible.
Benazepril
Adverse Effect: Increase in mean arterial pressure # Clinical Management: Monitor for the increase in arterial pressure and adjust the dose accordingly when ACE inhibitors like Benazepril and Rofecoxib are administered together.
Frusemide
Adverse Effect: Reduction in the natriuretic effect of Furosemide # Clinical Management: Monitor for the therapeutic effects and adjust the dose accordingly.
Lithium
Adverse Effect: Elevation of plasma Lithium levels and a reduction in renal Lithium clearance # Clinical Management: Monitor for signs of Lithium toxicity when the drugs are administered concomitantly.
Methotrexate
Adverse Effect: Elevation of plasma Methotrexate levels and a reduction in renal Methotrexate clearance # Clinical Management: Monitor Methotrexate- related toxicity when both the drugs are administered together.
Rifampicin
Adverse Effect: Decrease in the plasma concentration of Rofecoxib due to the hepatic microsomal induction activity of Rifampicin # Clinical Management: Monitor the therapeutic effects and increase the dose of Rofecoxib if required.
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