Cotrimoxazole
Adverse Effect: an increased risk of megaloblastic anemia and pancytopenia Clinical Management: Avoid giving cotrimoxazole (sulfamethoxazole/trimethoprim) and pyrimethamine concomitantly. Should it become clinically necessary to coadminister these agents, aggressively monitor complete blood counts and observe the patient for bruising and excessive bleeding.
Lorazepam
Adverse Effect: elevated liver function tests in some patients Clinical Management: If lorazepam and pyrimethamine are to be given concomitantly, monitor liver function regularly |