Bupivacaine Comb.
Adverse Effect: decreased phenothiazine serum concentrations, decreased phenothiazine effectiveness, enhanced anticholinergic effects (ileus, hyperpyrexia, sedation, dry mouth) Clinical Management: Anticholinergics (benztropine, orphenadrine, procyclidine, trihexyphenidyl) should not be used routinely with phenothiazine derivatives as prophylaxis against possible extrapyramidal symptoms; use should be reserved for situations where EPS occur and lowering of the antipsychotic dosage is not possible.
Cisapride
Adverse Effect: Loss of cisapride efficacy Clinical Management: The beneficial effects of cisapride are expected to be largely lost if an anticholinergic medication such as procyclidine is given concomitantly.
Fluphenazine
Adverse Effect: decreased phenothiazine serum concentrations, decreased phenothiazine effectiveness, enhanced anticholinergic effects (ileus, hyperpyrexia, sedation, dry mouth) Clinical Management: Anticholinergics (benztropine, orphenadrine, procyclidine, trihexyphenidyl) should not be used routinely with phenothiazine derivatives as prophylaxis against possible extrapyramidal symptoms; use should be reserved for situations where EPS occur and lowering of the antipsychotic dosage is not possible.
Haloperidol
Adverse Effect: excessive anticholinergic effects (sedation, constipation, dry mouth) Clinical Management: Use this combination only when clearly indicated. Monitor for excessive anticholinergic effects. A dosage adjustment for haloperidol may be required
Procainamide
Adverse Effect: Additive antivagal effects on A-V nodal conduction Clinical Management: Monitor heart rate and ECG in patients given procainamide concomitantly with Procyclidine .
Thioridazine
Adverse Effect: decreased phenothiazine serum concentrations, decreased phenothiazine effectiveness, enhanced anticholinergic effects (ileus, hyperpyrexia, sedation, dry mouth) Clinical Management: Anticholinergics (benztropine, orphenadrine, procyclidine, trihexyphenidyl) should not be used routinely with phenothiazine derivatives as prophylaxis against possible extrapyramidal symptoms; use should be reserved for situations where EPS occur and lowering of the antipsychotic dosage is not possible.
Trifluoperazine
Adverse Effect: decreased Trifluoperazine serum concentrations, decreased Trifluoperazine effectiveness, enhanced anticholinergic effects (ileus, hyperpyrexia, sedation, dry mouth) Clinical Management: Anticholinergics (benztropine, orphenadrine, procyclidine, trihexyphenidyl) should not be used routinely with Trifluoperazine derivatives as prophylaxis against possible extrapyramidal symptoms; use should be reserved for situations where EPS occur and lowering of the antipsychotic dosage is not possible |