Amphotericin B, diuretics: Enhanced hypokalemia. Monitor serum potassium level. Antacids, cholesryramine, colestipol: Decreased prednisolone absorption. Separate administration times.
Barbiturates, phenytoin, rifampin: Decreased cor-ticosteroid effects because of increased hepatic metabolism. Monitor child.
Cardiac glycosides: Possible hypokalemia may increase risk of toxicity in children receiving these drugs. Monitor serum potassium level.
Estrogens: Reduced metabolism of prednisolone via increased level of transcortin; half-life of cor-ticosteroid prolonged because of increased protein-binding. Adjust dosage as needed.
Insulin, oral antidiabetics: Hyperglycemia. Adjust dosages of these drugs as needed.
Isoniazid, salicylates: Increased metabolism of these drugs. Monitor child closely.
Oral anticoagulants: Decreased effects. Monitor PT and INR.
Ulcerogenic drugs (such as NSAIDs): Increased risk of GI ulceration. Use together cautiously. |