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| Dosages: | | IV: Highly emetogenic chemotherapy (First day): 8mg by slow I.V injection immediately before chemotherapy as a single dose; or same treatment followed by two 8mg doses in 2-4 hours apart; or constant infusion of 1mg/hour for 24 hours; or single dose of 32mg diluted in 50-100ml of saline or other compatible infusion fluid& infused over a period of not less than 15 minutes immediately before chemotherapy.
Oral: (second to fifth day): 8mg twice daily for 5 days.
IV: Emetogenic chemotherapy/radiotherapy (First day): 8mg as slow IV injection immediately before chemotherapy/radiotherapy.
Oral: First day: 8mg 1-2 hours before chemotherapy/radiotherapy; second to fifth day: 8mg twice daily for 5 days.
Oral: Post-operative nausea & vomiting: 8mg 1 hour before giving anaesthesia followed by two 8mg doses at 8 hours interval.
IV: Post-operative nausea & vomiting: single dose of undiluted 4mg by slow IV injection at induction of anaesthesia.
In case of impaired hepatic function the daily dose should not exceed 8mg.
In highly emetogenic chemotherapy the efficacy of the drug in the first 24 hours is enhanced by the addition of a single IV dose of 20mg of Dexamethasone sodium phosphate prior to chemotherapy. |
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