Acenocoumarol Adverse Effect an increased risk of bleedingClinical Management In patients receiving Acenocoumarol , the prothrombin time (PT) or international normalized ratio (INR) should be closely monitored with the addition and withdrawal of treatment with miconazole, and should be reassessed periodically during concurrent therapy. Adjustments of the acenocoumarol dose may be necessary .
Amphotericin B Adverse Effect Pharmacodynamic antagonism between these agentsClinical Management Monitor patients for therapeutic effectiveness if these medications are given concomitantly.
Glimepiride Adverse Effect severe hypoglycemiaClinical Management During concurrent therapy, monitor blood glucose closely and observe for signs and symptoms of hypoglycemia (eg; fatigue, restlessness, malaise, irritability, weakness, increased perspiration).
PhenindioneAdverse Effect An increased risk of bleedingClinical Management In patients receiving Phenindione , the prothrombin time (PT) or international normalized ratio (INR) should be closely monitored with the addition and withdrawal of treatment with miconazole, and should be reassessed periodically during concurrent therapy. Adjustments of the phenindione dose may be necessary in order to maintain the desired level of anticoagulation.
Phenytoin Adverse Effect an increased risk of phenytoin toxicity (ataxia, hyperreflexia, nystagmus, tremor)Clinical Management Avoid systemic imidazole antifungal therapy if possible. Monitor patient closely for signs or symptoms of phenytoin toxicity. Serum level monitoring of phenytoin may be helpful interpreting suspected toxicity.
Warfarin Adverse Effect an increased risk of bleedingClinical Management: In patients receiving Miconazole with warfarin, the prothrombin time (PT) or international normalized ratio (INR) should be closely monitored with the addition and withdrawal of treatment with miconazole, and should be reassessed periodically during concurrent therapy.
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