AcenocoumarolAdverse Effect: Decreased effectiveness of acenocoumarolClinical Management: Monitor the prothrombin time (PT) in patients stabilized on acenocoumarol therapy who add mianserin to their treatment regimen. An increase in the acenocoumarol dose may be necessary to maintain the desired level of anticoagulation.
CarbamazepineAdverse Effect: decreased mianserin serum concentrationsClinical Management: Serum levels and clinical response to mianserin should be carefully monitored if carbamazepine is added to therapy or discontinued. |