Bacterial infection
Neonate < 4 wk and < 1.2 kg: 7.5 mg/kg PO, IV q 48 h.
Neonate < 1wk and 1.2-2 kg: 7.5 mg/kg PO, IV q 24 h.
Neonate < 1 wk and > 2 kg: 7.5 mg/kg PO, IV q 12 h.
Neonate > 1 wk and 1.2-2 kg: 7.5 mg/kg PO, IV q 12 h.
Neonate > 1 wk and > 2 kg: 15 mg/kg PO, IV q 12 h.
Infant, child: 7.5 mg/kg PO, IV q 6 h. Max 4 gram/day.
Adult: 15 mg/kg IV over 1 h. Maintenance 7.5 mg/kg IV, PO q 6 h. Give 1st maintenance dose 6 h after loading dose. Max 4 gram qd.
Clostridium difficile
Child: 30-50 mg/kg PO qd in 3-4 divided doses × 7-10 day. Dont exceed adult dose.
Adult: 750 mg-2 gram PO qd in 3-4 divided doses × 7-14 day.
H. pylori associated with peptic ulcer disease
Child: 15-20 mg/kg PO qd divided in 2 doses × 4 wk (with amoxicillin or bismuth subsalicylate).
Adult: 250-500 mg PO tid (with at least 1 other drug active against H. pylori). |