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| Interactions: | BezafibrateAdverse Effect an increased risk of myopathy or rhabdomyolysisClinical Management If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis.
Clarithromycin Adverse Effect an increased risk of myopathy or rhabdomyolysis Clinical Management:If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis .
Cyclosporin Adverse Effect Myositis, Cyclosporine reduces the clearance of Lovastatin when administered together Clinical Management: Monitor for signs and symptoms of myositis & avoid the concurrent use if possible.
Diltiazem Adverse Effect increased plasma concentrations of lovastatin and increased risk of myopathy or rhabdomyolysisClinical Management If concurrent therapy with lovastatin and diltiazem is deemed necessary, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis (muscle pain, tenderness, or weakness). Monitor creatine kinase (CK) levels and discontinue use if CK levels show a marked increase, or if myopathy or rhabdomyolysis is diagnosed or suspected.
Erythromycin Adverse Effect myopathy or rhabdomyolysisClinical Management If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis.
FluconazoleAdverse Effect an increased risk of myopathy or rhabdomyolysisClinical Management If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis
Fluoxetine Decreased hepatic metabolism of simvastatin and atorvastatin
Gemfibrozil Adverse Effect an increased risk of myopathy or rhabdomyolysisClinical Management The combined use of gemfibrozil and statins should generally be avoided. If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis
ItraconazoleAdverse Effect an increased risk of myopathy or rhabdomyolysisClinical Management Concomitant use of itraconazole and lovastatin is contraindicated.
Ketoconazole Adverse Effect an increased risk of myopathy or rhabdomyolysisClinical Management If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis.
Nicotinic AcidAdverse Effect an increased risk of myopathy or rhabdomyolysisClinical Management If concurrent therapy is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis.
WarfarinAdverse Effect an increased risk of bleeding Clinical Management:Warfarin dosage adjustments may be required. |
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