|  | | Interactions: |  | Diclofenac Adverse Effect Increase in the free fraction of Diclofenac when both the drugs are administered together     Clinical Management: Monitor for the therapeutic effects and adjust the dosage accordingly.Ibuprofen Adverse Effect Increase in the free fraction of Ibuprofen when both the drugs are administered together     Clinical Management: Monitor for the therapeutic effects and adjust the dosage accordingly.RifampicinAdverse Effect Significant increase in the plasma concentration of Lefulnomide     # Clinical Management: Concomitant administration should be done with caution.Tolbutamide Adverse Effect Increase in the free fraction of Tolbutamide when both the drugs are administered together     Clinical Management: Monitor for the therapeutic effects and adjust the dosage accordingly. | 
 |  |