Dosages & Reactions

Interactions:

Acarbose
Adverse Effect: An increased risk of hypoglycemia
Clinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Glibenclamide . Doses of either or both drugs may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
Antacids Comb.
Adverse Effect: Hypoglycemia (CNS depression, seizures)
Clinical Management: Concurrent administration of glyburide and antacids is not recommended. If concurrent use cannot be avoided, monitor blood glucose for signs of hypoglycemia upon initiation of antacids. Reduce dose of glyburide as needed on the basis of serum blood glucose concentrations.
Atenolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Bisoprolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Carvedilol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Celecoxib
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Celecoxib is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Celecoxib is added to therapy.
Celiprolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Cimetidine
Adverse Effect: Hypoglycemia
Clinical Management: Concurrent administration of glyburide and cimetidine is not recommended. If concurrent use cannot be avoided, monitor blood glucose for signs of hypoglycemia upon initiation of cimetidine. Reduce dose of glyburide as needed on the basis of serum blood glucose concentrations. Suggest switching to another anti-ulcer medication (eg, sucralfate) which has less potential to alter the pharmacokinetics of glyburide.
Ciprofloxacin
Adverse Effect: severe hypoglycemia
Clinical Management: If concurrent therapy with ciprofloxacin and Glibenclamide is necessary, closely monitor the blood glucose level and adjust the dosing of Glibenclamide as indicated.
Cotrimoxazole
Adverse Effect: Enhanced hypoglycemic effects
Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glibenclamide . If concomitant therapy is required, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Diclofenac Preps.
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Diclofenac Preps.is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Diclofenac Preps.added to therapy.
Fluconazole
Adverse Effect: Hypoglycemia (CNS depression, seizures)
Clinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs of hypoglycemia.
Flurbiprofen
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Flurbiprofen is coadministered with Glibenclamide, patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Flurbiprofen is added to therapy.
Gemfibrozil
Adverse Effect: Hypoglycemia
Clinical Management: If concurrent therapy is required, monitor the patients blood glucose carefully. A reduction in the dose of glyburide may be required.
Ibuprofen
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Ibuprofen is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Ibuprofen is added to therapy.
Indomethacin
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Indomethacin is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Indomethacin is added to therapy.
Ketoprofen
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Ketoprofen is coadministered with Glibenclamide, patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Ketoprofen is added to therapy.
Ketorolac
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Ketorolac is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Ketorolac is added to therapy.
Labetalol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Mefenamic Acid
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Mefenamic Acid is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Mefenamic Acid is added to therapy.
Meloxicam
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Meloxicam is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Meloxicam is added to therapy.
Metoprolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Nabumetone
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Nabumetone is coadministered with Glibenclamide drug, patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Nabumetone is added to therapy.
Naproxen
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Naproxen is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Naproxen is added to therapy.
Nimesulide
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Nimesulide is coadministered with Glibenclamide, patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Nimesulide is added to therapy.
Oxprenolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Oxyphenbutazone
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Oxyphenbutazone is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Oxyphenbutazone is added to therapy.
Paracetamol
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Paracetamol is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Paracetamol is added to therapy.
Phenacetin
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Phenacetin is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Phenacetin is added to therapy.
Phenylbutazone
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Phenylbutazone is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Phenylbutazone is added to therapy.
Pindolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Piroxicam
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Piroxicam is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Piroxicam is added to therapy.
Propranolol
Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects.Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Selegiline
Adverse Effect: excessive hypoglycemia, CNS depression, and seizures
Clinical Management: Blood glucose levels should be closely monitored when Selegiline is added or discontinued in a patient receiving Glibenclamide .
Sulphadiazine
Adverse Effect: enhanced hypoglycemic effects
Clinical Management: Avoid the use of Sulphadiazine in patients who are taking Glibenclamide . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Tenoxicam
Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Tenoxicam is coadministered with Glibenclamide , patients should be monitored more closely for hypoglycemia. Dose of Glibenclamide may need to be reduced when Tenoxicam is added to therapy.
Warfarin
Adverse Effect: an increased risk of bleeding

Gabapentin

Ganciclovir(DHPG)

GentamicinSulfate

Glucagon

GriseofulvinMicrosize

Guaifenesin

Gammabenzene Hexachloride