Antacids containing magnesium or aluminum hydroxides: May produce enhanced adverse effects, such as diarrhea or constipation, Monitor child for adverse effects.
Dapsone, ketoconazole, other drugs that require gastric acid for adequate absorption:May be ren-dered ineffective because of buffering action of didanosine formulations on gastric acid. Admin-ister such drugs 2 hours before didanosine.
Fluoroquinolones, tetracyclines: May show de-creased absorption because of buffering ingredients in didanosine tablets or antacids in pediatric suspension. Monitor child for drug effects. |