Central cranial diabetes insipidus, temporary polyuria, polydipsia from pituitary trauma
Child 3 month-12 yr: 5-30 mcg (0.05-0.3 ml) intranasally qd in 1-2 doses.
Adolescent, adult: 10-40 mcg (0.1-0.4 ml) intranasally in 1-3 divided doses qd. Adjust morning and pm doses separately for adequate diurnal rhythm of H2O turnover. Or 0.05 mg PO bid. Adjust based on response to range of 0.1-1.2 mg qd, in 2-3 divided doses. Optimal range 0.1-1.8 mg qd in divided doses. Or give 0.5 ml (2 mcg)-1 ml (4 mcg) IV or SC qd, usually in 2 divided doses.
Hemophilia A, von Willebrands disease
Infant, child > 3 month, adult: 0.3 mcg/kg dil and infusion IV over 15-30 min. Repeat dose prn as indicated by lab response and pt condition. Or give 150 mcg (0.1 ml)/nostril.
Primary nocturnal enuresis
Child = 6 yr: 20 mcg (0.2 ml), intranasally hs (10 mcg/nostril). Adjust dose according to response. Max 40 mcg qd. Or 0.2 mg PO hs. Adjust up to 0.6 mg to achieve desired response. For pts previously receiving intranasal DDAVP, start PO the night following (24 hr after) the last intranasal dose. |