Iron intoxication
Child > 3 yr, adult: 1 gram IM (preferred) or IV, then 500 mg IM or IV q 4 h × 2 doses; then 500 mg IM or IV q 4-12 h prn. Max IV infusion rate 15 mg/kg/h. Max 6 gram/24 h. (IV infusion reserved for pts in cardiovascular collapse) Or 20 mg/kg (or 600 mg/m2) IM or slow IV, then 10 mg/kg (or 300 mg/m2) q 4 h × 2 doses, then 10 mg/kg (or 300 mg/m2) q 4-12 h prn.
Chronic iron overload from multiple transfusions
Child > 3 yr, adult: 500-1,000 mg IM qd and 2 gram slow IV infusion in separate solution with each U of blood transfused. Max IV infusion rate 15 mg/kg/h. Or 1-2 gram via SC infusion pump over 8-24 h. |