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| Interactions: | Clozapine
Adverse Effect: an increased risk of gastrointestinal bleeding and hyperglycemia Clinical Management: Caution should be observed when clozapine and buspirone are coadministered.
Diltiazem
Adverse Effect: an increased risk of enhanced buspirone effects Clinical Management: Monitor patients who are receiving diltiazem and buspirone for enhanced sedative effects of buspirone. Low doses of buspirone should be employed.
Erythromycin
Adverse Effect: increased buspirone plasma concentrations; increased buspirone side effects (impaired psychomotor performance, sedation) Clinical Management: Erythromycin should be avoided in patients treated with buspirone.
Fluoxetine
Adverse Effect: worsening of psychiatric symptoms Clinical Management: If possible, the combination of fluoxetine and buspirone should be avoided.
Haloperidol
Adverse Effect: An increased risk of haloperidol adverse effects (akathisia, tongue stiffness) Clinical Management: Monitor patients for excessive haloperidol adverse effects (akathisia, tongue stiffness). A dosage adjustment of haloperidol may be required.
Itraconazole
Adverse Effect: increased buspirone plasma concentrations; increased buspirone side effects (impaired psychomotor performance, sedation) Clinical Management: Itraconazole should be avoided in patients treated with buspirone.
Rifampicin
Adverse Effect: reduced anxiolytic effects of buspirone Clinical Management: Monitor patients receiving rifampin and buspirone for buspirone efficacy. Doses of buspirone may need to be increased when rifampin is coadministered.
Selegiline
Adverse Effect: hypertensive crisis Clinical Management: Coadministration of buspirone with Selegiline is not recommended.
Trazadone
Adverse Effect: An elevated SGPT (ALT) level Clinical Management: During concurrent therapy with trazodone and buspirone, monitor liver function closely.
Verapamil
Adverse Effect: an increased risk of enhanced buspirone effects Clinical Management: Monitor patients who are receiving verapamil and buspirone for enhanced sedative effects of buspirone.
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