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| Dosages: | Symptomatic HIV, AIDS, advanced AIDS-related complex-
Infant, child 3 month-12 yr: 180 mg/m2 q 6 h (720 mg/m2/day). Max 200 mg q 6 h.
Child = 12 yr, adult: 100 mg PO q 4 h (600 mg qd). Or 1 mg/kg IV infusion at constant rate over 1 h q 4 h to total 6 mg/kg/day.
Asymptomatic HIV infection-
Infant, child 3 month-12 yr: 180 mg/m2 q 6 h (720 mg/m2 PO qd) in divided doses q 6 h. Max 200 mg q 6 h.
Child = 12 yr, adult: 100 mg PO q 4 h while awake (500 mg qd). Or 1 mg/kg IV orier 1 h q 4 h while awake (5 mg/kg qd).
Maternal-fetal HIV transmission-
Neonate: 2 mg/kg PO or 1.5 mg/kg IV q 6 h over 30 min starting 12 h after birth until age 6 wk.
Adult: Maternal dose: 100 mg PO q 4 h while awake (5 doses qd) until onset of labor. During labor, delivery: 2 mg/kg IV over 1 h then 1 mg/kg/h continue infusion until umbilical cord clamped. |
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