|
| Interactions: | Benzocaine
Adverse Effect: antagonism of the sulfonamides antibacterial effect Clinical Management: Avoid use of Benzocaine or para-aminobenzoic acid (PABA) derivatives in patients receiving Sulphadiazine, consider alternative therapy.
Chlorpropamide
Adverse Effect: enhanced hypoglycemic effects
Glibenclamide
Adverse Effect: enhanced hypoglycemic effects Clinical Management: Avoid the use of Sulphadiazine in patients who are taking Glibenclamide . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Gliclazide
Adverse Effect: enhanced hypoglycemic effects Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Gliclazide . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Glimepiride
Adverse Effect: enhanced hypoglycemic effects Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glimepiride . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Glipizide
Adverse Effect: enhanced hypoglycemic effects Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glipizide . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Phenytoin
Adverse Effect: An increased risk of phenytoin toxicity (ataxia, nystagmus, hyperreflexia, lethargy) Clinical Management: Monitor the patient for evidence of phenytoin toxicity such as nystagmus and ataxia if sulfadiazine is added to therapy. If the patient exhibits signs of toxicity, or if the patient receives sulfadiazine for more than five days, a serum phenytoin level should be considered and the dose adjusted if needed.
Tolbutamide
Adverse Effect: enhanced hypoglycemic effects Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Tolbutamide . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required. |
|
|