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| Interactions: | Cimetidine
Adverse Effect: Decreased cimetidine absorption, decreased sucralfate effectiveness Clinical Management: Concurrent administration of cimetidine and sucralfate is not recommended. If concurrent use cannot be avoided, administer sucralfate at least two hours after the cimetidine dose.
Ciprofloxacin
Adverse Effect: decreased ciprofloxacin effectiveness Clinical Management: Concurrent administration of ciprofloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, ciprofloxacin should be taken at least two hours before or six hours after sucralfate. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antibiotic efficacy.
Digoxin
Adverse Effect: decreased digoxin effectiveness Clinical Management: Concurrent administration of sucralfate and digoxin is not recommended. If concurrent use cannot be avoided, sucralfate should be taken at least two hours after digoxin.
Ketoconazole
Adverse Effect: Decreased ketoconazole effectiveness Clinical Management: Concurrent administration of ketoconazole and sucralfate is not recommended. If concurrent use cannot be avoided, ketoconazole should be taken at least two hours before sucralfate. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antifungal efficacy.
Lansoprazole
Adverse Effect: Reduced lansoprazole bioavailability Clinical Management: Lansoprazole should be administered at least 30 minutes prior to sucralfate therapy.
Levofloxacin
Adverse Effect: Decreased levofloxacin effectiveness Clinical Management: Administer levofloxacin at least two hours before or two hours after sucralfate.
Lomefloxacin
Adverse Effect: decreased lomefloxacin effectiveness Clinical Management: Concurrent administration of lomefloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, lomefloxacin should be taken at least two hours before or four hours after sucralfate.
Nalidixic Acid
Adverse Effect: decreased nalidixic acid effectiveness Clinical Management: Concurrent administration of nalidixic acid and sucralfate is not recommended. If concurrent use cannot be avoided, nalidixic acid should be taken at least two hours before or six hours after sucralfate. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antibiotic efficacy.
Norfloxacin
Adverse Effect: decreased norfloxacin effectiveness Clinical Management: Concurrent administration of norfloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, norfloxacin should be taken at least two hours before or six hours after sucralfate.
Ofloxacin
Adverse Effect: decreased ofloxacin effectiveness Clinical Management: Concurrent administration of ofloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, ofloxacin should be taken at least two hours before or two hours after sucralfate.
Pefloxacin
Adverse Effect: decreased pefloxacin effectiveness Clinical Management: Concurrent administration of pefloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, norfloxacin should be taken at least two hours before or six hours after sucralfate.
Phenytoin
Adverse Effect: Decreased phenytoin effectiveness Clinical Management: For patients taking both sucralfate and phenytoin, they should be counseled on the potential for decreased phenytoin effectiveness and instructed to separate their phenytoin and sucralfate doses by at least two hours.
Quinidine
Adverse Effect: Decreased quinidine effectiveness Clinical Management: Concurrent administration of quinidine and sucralfate is not recommended. If concurrent use cannot be avoided, sucralfate should be taken at least four hours after quinidine.
Sparfloxacin
Adverse Effect: Decreased sparfloxacin efficacy Clinical Management: Concurrent administration of sparfloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, sparfloxacin should be taken at least two hours before or four hours after sucralfate. Because staggered administration may not be completely reliable, monitor these patients for continued antibiotic efficacy.
Warfarin
Adverse Effect: Decreased warfarin effectiveness Clinical Management: In patients receiving oral anticoagulant therapy with warfarin, the prothrombin time ratio or international normalized ratio (INR) should be closely monitored with the addition and withdrawal of treatment with sucralfate, and should be reassessed periodically during concurrent therapy. Adjustments of the warfarin dose may be necessary in order to maintain the desired level of anticoagulation |
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