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| Interactions: | AdrenalineAdverse Effect Hypertension, bradycardia, resistance to Adrenaline in anaphylaxisClinical Management Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If Levobunolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Amiodarone Adverse Effect hypotension, bradycardia, or cardiac arrestClinical Management Monitor cardiac function carefully. Amiodarone should be used with caution in patients receiving beta blockers particularly if there is suspicion of underlying dysfunction of the sinus node, such as bradycardia or sick sinus syndrome, or if there is partial AV block.
Amlodipine Adverse Effect hypotension and/or bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure.
BenidipineAdverse Effect hypotension and/or bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure.
Celecoxib Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Clonidine Adverse Effect exaggerated clonidine withdrawal response (acute hypertension)Clinical Management Patients to be withdrawn from clonidine who are concomitantly receiving Levobunolol should be monitored carefully for hypertension. Withdraw Levobunolol several days before a gradual lowering of clonidine doses. Alternatively, substitute labetalol (an alpha/beta blocker) for clonidine.
Diltiazem Adverse Effect Hypotension, bradycardia, AV conduction disturbancesClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure. A dosage adjustment for hepatically metabolized beta blockers may be required.
Felodipine Adverse Effect hypotension and/or bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure.
Flunarizine Adverse Effect Hypotension, bradycardia, and AV conduction disturbancesClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure or bradyarrhythmias.
Flurbiprofen Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
IbuprofenAdverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Ibuprofen Comb.Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Indomethacin Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Ketoprofen Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Ketorolac Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
LacidipineAdverse Effect hypotension and/or bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure.
LidoflazineAdverse Effect Hypotension, bradycardia, and AV conduction disturbancesClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure or bradyarrhythmias.
Mefenamic Acid Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
MeloxicamAdverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Methyldopa Adverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
Nabumetone Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
NaproxenAdverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Nifedipine Adverse Effect hypotension and/or bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure.
Nimesulide Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Nitrendipine Adverse Effect hypotension and/or bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure.
Oxyphenbutazone Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Paracetamol Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Paracetamol Comb.Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
PhenacetinAdverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
PhenylbutazoneAdverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Piroxicam Adverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Prazosin - BPH Adverse Effect An exaggerated hypotensive response to the first dose of the Prazosin - BPHClinical Management When concurrent therapy with Prazosin - BPH and Levobunolol is required, initiate Prazosin - BPH with a smaller than usual dose, preferably at bedtime. Monitor the patient closely for hypotension.
RitodrineAdverse Effect Potential interference with tocolytic action of ritodrineClinical Management It is possible to successfully treat a patient with both a beta blocker and a beta mimetic if an appropriate dosage is found and the clinical response is monitored.
TenoxicamAdverse Effect Decreased antihypertensive effectClinical Management If concurrent therapy is required, monitor the patients blood pressure carefully and assess the need for a dosage adjustment for the beta blocker.
Terazosin - BPH Adverse Effect An exaggerated hypotensive response to the first dose of Terazosin - BPHClinical Management When concurrent therapy with Terazosin - BPH and Levobunolol is required, initiate Terazosin - BPH with a smaller than usual dose, preferably at bedtime. Monitor the patient closely for hypotension.
Verapamil Adverse Effect Hypotension, bradycardiaClinical Management If concurrent therapy is required, monitor cardiac function carefully, particularly in patients predisposed to heart failure. |
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