Cotrimoxazole Adverse Effect: an increased risk of lamivudine adverse effects
Clinical Management: Clinicians should be aware that the combined use of cotrimoxazole and lamivudine may cause elevated lamivudine serum concentrations. Patients who are given this combination of medications should be followed for excessive adverse effects related to lamivudine (GI disturbances, headache, fatigue, myalgia, and rarely neutropenia). Adjustments in lamivudine dosing may be required. |