Prophylaxis of malaria
Infant, child: 5 mg, calculated as base/kg; on same day each wk.Start 2 wk before exposure. If unable, give 10 mg base/kg in 2 divided doses 6 h apart. Dont exceed adult dose.
Adult: 400 mg sulfate (310-mg base) PO q wk on same day each wk. Start 2 wk before entering endemic area and continue × 8 wk after leaving.
Acute malaria
Infant, child: 10 mg base/kg; max 620 mg base/dose. Then, 5 mg base/kg, max 310 mg base/dose, 6 h after 1st dose; 5 mg base/kg 18 h after 2nd dose; 5 mg base/kg 24 h after 3rd dose.
Adult: 800 mg (620-mg base), then 400 mg (310-mg base) in 6-8 h and 400 mg (310-mg base) on each of 2 consecutive day. |