Disseminated intravascular coagulation
Child: 25-50 U/kg IV q 4 h as single inj or continue infusion. Discontinue if no improvement in 4-8 h.
Adult: 50-100 U/kg IV q 4 h as single inj or continue infusion. Discontinue if no improvement in 4-8 h.
DVT, PE
Child: 50 U/kg IV bolus, then maintenance at 50-100 U/kg IV drip q 4 h. Cont infusion: 20,000 U/m2 day. Adjust dose based on PTT.
Adult: 5,000-10,000 U IV push, then adjust dose based on PTT and give IV q 4 h (usually 4,000-5,000 U); or 5,000 U IV bolus, then 20,000-40,000 U in 24 h by IV infusion pump. Wait 4-6 h after bolus and adjust rate based on PTT.
Maintain patency of IV indwelling catheter
Child, adult: 10-100 U IV flush.
Embolism prophylaxis, post MI, cerebral thrombosis in evolving CVA, left ventricular thrombi
Adult: 5,000 U SC q 8-12 h. |