Fluoxetine
Adverse Effect: decreased fluoxetine efficacy Clinical Management: Monitor patients for a reduction in fluoxetine efficacy. When cyproheptadine is coadministered with fluoxetine, fluoxetine doses might need to be adjusted upward. In some cases, it may be necessary to withdraw cyproheptadine.
Selegiline
Adverse Effect: prolonged and intensified anticholinergic effects Clinical Management: Concurrent use of cyproheptadine and Selegiline is contraindicated. |