Pulm, extrapulm TB
Child: 10-20 mg/kg; max 1,000 mg, qd in 2 divided doses.
Adult: 250 mg PO q 12 h × 2 wk; then, if blood levels < 25-30 mg/ml and pt shows no signs of toxicity, increase to 250 mg PO q 8 h × 2 wk. If optimum blood levels still arent achieved and pt shows no signs of toxicity, increase to 250 mg PO q 6 h. Max 1 gram qd. If CNS toxicity occurs, discontinue × 1 wk, then resume at 250 mg/day × 2 wk. If no serious toxic effects occur, increase by 250 mg q 10 day until blood levels reach 25-30 µgram/ml. |