Allopurinol
Cyclophosphamide toxicity (bone marrow suppression, nausea, vomiting) Clinical Management: If possible avoid concurrent administration
Chloramphenicol
Adverse Effect: Decreased cyclophosphamide effectiveness Clinical Management: Avoid this combination if possible due to unpredictable cyclophosphamide efficacy.
Digoxin
Adverse Effect: Decreased digoxin effectiveness Clinical Management: Substitute digoxin in liquid form (liquid or capsules containing liquid digoxin) for digoxin tablets, or substitute digitoxin, which is not affected by this interaction, for digoxin.
Indomethacin
Adverse Effect: Fluid retention Clinical Management: Monitor patients for fluid retention.
Phenobarbitone
Adverse Effect: Decreased cyclophosphamide efficacy
Succinyl Choline
An increased risk of potentiated succinylcholine efficacy Clinical Management: If cyclophosphamide has been administered within 10 days of succinylcholine administration, extreme caution should be used during and after succinylcholine administration.
Tamoxifen
An increased risk of thromboembolism Clinical Management: In patients undergoing therapy with tamoxifen for breast cancer, the risks of adding cyclophosphamide should be weighed against the potential benefits. |