Arthritis
Child: 80-130 mg/kg PO qd in divided doses.
Adult: 3.6-5.4 gram PO qd in divided doses.
Mild pain, fever
Child 2-11 yr: 1.5 gram/m2 PO or PR qd or 65 mg/kg PO or PR qd divided q 4-6 h prn. Max 5 doses/day. Max rectal dose, 2.5 gram/m2/day.
Child = 11 yr, adult: 325-650 mg PO or PR q 4 h prn. Max 4 gram/day.
Juvenile rheumatoid arthritis
Child = 25 kg: 60-130 mg/kg/day PO in divided doses.
Child > 25 kg: 2.4-3.6 gram qd in divided doses. Increase by 10 mg/kg/day q 7 day prn. Maintenance dose 80-100 mg/kg/day.
Rheumatic fever
Child: 90-130 mg/kg PO qd divided q 4-6 h.
Adult: 4.9-7.8 gram PO qd divided q 4 to 6 h × 1-2 wk; then decrease to 60-70 mg/kg/day × 1-6 wk; then gradually withdraw over 1-2 wk. |