Amitriptyline
Adverse Effect: hypertension, cardiac arrhythmias, and tachycardia Clinical Management: The vasoconstriction and other alpha-adrenergic effects of sympathomimetic drugs are substantially enhanced in the presence of Amitriptyline. Concomitant use should be avoided. If these drugs are given together, careful monitoring and a dose reduction of the sympathomimetic is required
Atenolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxisClinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Atenolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Bisoprolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Bisoprolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Carvedilol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If Carvedilol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Celiprolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Celiprolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Chlorpromazine
Adverse Effect: Concomitant administration antagonizes the peripheral vasoconstrictive effects and decreases the pressor effect Clinical Management: Monitor the therapeutic effects and adjust dose accordingly.
Clomipramine
Adverse Effect: hypertension, cardiac arrhythmias, and tachycardia Clinical Management: The vasoconstriction and other alpha-adrenergic effects of sympathomimetic drugs are substantially enhanced in the presence of Clomipramine . Concomitant use should be avoided. If these drugs are given together, careful monitoring and a dose reduction of the sympathomimetic is required
Dihydroergotoxine
Adverse Effect: Extreme elevation of blood pressure Clinical Management: The concurrent use of dihydroergotamine with Adrenaline is contraindicated.
Halothane
Adverse Effect: ventricular toxicity (ventricular arrhythmia) Clinical Management: Monitor for arrhythmias.
Imipramine
Adverse Effect: hypertension, cardiac arrhythmias, and tachycardia Clinical Management: The vasoconstriction and other alpha-adrenergic effects of sympathomimetic drugs are substantially enhanced in the presence of Imipramine. Concomitant use should be avoided. If these drugs are given together, careful monitoring and a dose reduction of the sympathomimetic is required
Labetalol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Labetalol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Levobunolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If Levobunolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Metoprolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Metoprolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Nortriptyline
Adverse Effect: hypertension, cardiac arrhythmias, and tachycardia Clinical Management: The vasoconstriction and other alpha-adrenergic effects of sympathomimetic drugs are substantially enhanced in the presence of Nortriptyline. Concomitant use should be avoided. If these drugs are given together, careful monitoring and a dose reduction of the sympathomimetic is required
Oxprenolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Oxprenolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Phenoxybenzamine
Adverse Effect: Adrenalins beta-adrenergic responses are exaggerated due to the alpha-adrenergic blockade resulting in hypotension, vasodilation, and tachycardia Clinical Management: Monitor for adverse effects and administer the drugs with caution.
Pindolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Pindolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Propranolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Propranolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Selegiline
Adverse Effect: Increased hypertensive effects Clinical Management: Monitor patients for clinical effects of acute blood pressure elevation (headache, arrhythmia, vomiting, fever). Should a hypertensive crisis develop, discontinue the drug and immediately begin medical therapy to lower blood pressure. Nitroprusside, nitroglycerin, phentolamine and labetalol are among the drugs that have been successfully used.
Sotalol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If a nonselective Sotalol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Timolol
Adverse Effect: Hypertension, bradycardia, resistance to Adrenaline in anaphylaxis Clinical Management: Concurrent use should be avoided if possible. However, if used concurrently, monitor blood pressure carefully. If Timolol causes resistance to Adrenaline in anaphylactic shock, glucagon may be effective in a dose of 1 mg or more intravenously every five minutes.
Trimipramine
Adverse Effect: hypertension, cardiac arrhythmias, and tachycardia Clinical Management: The vasoconstriction and other alpha-adrenergic effects of sympathomimetic drugs are substantially enhanced in the presence of Trimipramine. Concomitant use should be avoided. If these drugs are given together, careful monitoring and a dose reduction of the sympathomimetic is required |