|
| Interactions: | Antacids Comb.Adverse Effect: decreased norfloxacin efficacyClinical Management: Concurrent administration of norfloxacin and antacids is not recommended. If concurrent use cannot be avoided, norfloxacin should be taken at least two hours before or two hours after the antacid dose. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antibiotic efficacy. An H2 blocker such as ranitidine may be an alternative to antacids in some clinical situations.
NitrofurantoinAdverse Effect: antagonism of the antibacterial effect of norfloxacin Clinical Management: Do not administer nitrofurantoin and norfloxacin concurrently.
SucralfateAdverse Effect: decreased norfloxacin effectivenessClinical Management: Concurrent administration of norfloxacin and sucralfate is not recommended. If concurrent use cannot be avoided, norfloxacin should be taken at least two hours before or six hours after sucralfate.
TheophyllineAdverse Effect: theophylline toxicity (nausea, vomiting, palpitations, seizures) Clinical Management: Theophylline serum concentrations should be closely monitored when norfloxacin is added, discontinued, or when dosing changes occur. Dosing adjustments of theophylline may be necessary.
WarfarinAdverse Effect: An increased risk of bleeding Clinical Management: In patients receiving oral anticoagulant therapy with warfarin, the prothrombin time ratio or international normalized ratio (INR) should be closely monitored with the addition and withdrawal of treatment with norfloxacin, and should be reassessed periodically during concurrent therapy. Adjustments of the warfarin dose may be necessary in order to maintain the desired level of anticoagulation. |
|
|