CimetidineAdverse Effect: Nitrazepam toxicity (CNS depression)Clinical Management: Monitor for signs of Nitrazepam intoxication (eg, sedation, dizziness, ataxia, weakness, decreased cognition or motor performance). If symptoms are present, reduce Nitrazepam dose or consider switching to a benzodiazepine eliminated by glucuronidation (eg, lorazepam, oxazepam, temazepam).
ProbenecidAdverse Effect: CNS depressionClinical Management: Monitor for signs of Nitrazepam intoxication (eg, sedation, dizziness, ataxia, weakness, decreased cognition or motor performance). If symptoms are present, reduce nitrazepam dose.
RifampicinAdverse Effect: Decreased nitrazepam effectivenessClinical Management: Monitor for signs of Nitrazepam clinical effectiveness. Concurrent use of rifampin and nitrazepam may require higher doses of nitrazepam.
TheophyllineAdverse Effect: decreased Nitrazepam effectivenessClinical Management: Monitor the patient for Nitrazepam clinical effectiveness. |