Patent ductus arteriosus closure in premature infant
Neonate < 48 h: 0.2 mg/kg IV, then 2 doses of 0.1 mg/kg 12-24 h.
Neonate 2-7 day: 0.2 mg/kg IV, then 2 doses of 0.2 mg/kg q 12-24 h.
Neonate > 7 day: 0.2 mg/kg IV, then 2 doses of 0.25 mg/kg q 12-24 h.
Arthritis, ankylosing spondylitis, juvenile RA
Child 2-14 yr: 2 mg/kg PO qd in divided doses using conventional caps. Increase to 4 mg/kg qd in divided doses, max 200 mg qd. As symptoms subside, decrease dose to lowest effective level until drug is discontinued.
Adult: 25 mg PO bid or tid with food or antacid; increase by 25-50 mg/day q 7 day up to 200 mg qd; or 50 mg PR qid. Or sustained-release caps: 75 mg in morning or hs, then 75 mg bid prn.
Idiopathic pericarditis, postpericardiotomy pericarditis
Child: 50-100 mg PO qd in 2-4 divided doses. |