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| Interactions: | Acarbose Adverse Effect: An increased risk of hypoglycemia
Clinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Glipizide . Dose of either or both drugs may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
Antacids CombAdverse Effect: Hypoglycemia (CNS depression, seizures)
Clinical Management: Concurrent administration of glipizide and antacids is not recommended. If concurrent use cannot be avoided, monitor blood glucose for signs of hypoglycemia upon initiation of antacids. Reduce dose of glipizide as needed on the basis of serum blood glucose concentrations.
Atenolol Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Bisoprolol Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
CarvedilolAdverse Effect: Hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Celecoxib Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Celecoxib is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Celecoxib is added to therapy.
Celiprolol Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
CimetidineAdverse Effect: hypoglycemia
Clinical Management: Concurrent administration of glipizide and cimetidine is not recommended. If concurrent use cannot be avoided, monitor blood glucose for signs of hypoglycemia .
Cotrimoxazole Adverse Effect: enhanced hypoglycemic effects
Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glipizide . If concomitant therapy is required, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Diclofenac Preps. Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
Fluconazole Adverse Effect: Hypoglycemia (CNS depression, seizures)
Clinical Management: During concurrent therapy, monitor blood glucose closely and observe for signs of hypoglycemia.
Flurbiprofen Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Flurbiprofen is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Flurbiprofen is added to therapy.
Hydrochlorthiazide
Dosage adjustments with antidiabetics with other antihypertensives drugs additive effect or potentiation may occur
IbuprofenAdverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Ibuprofen is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Ibuprofen is added to therapy.
Indomethacin Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Indomethacin is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Indomethacin is added to therapy.
KetoprofenAdverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Ketoprofen is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Ketoprofen is added to therapy.
KetorolacAdverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Ketorolac is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Ketorolac is added to therapy.
Labetalol Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Mefenamic Acid Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Mefenamic Acid is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Mefenamic Acid added to therapy.
Meloxicam Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
MetoprololAdverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Nabumetone Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Nabumetone is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Dose of Glipizide may need to be reduced when Nabumetone is added to therapy.
NaproxenAdverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Naproxen is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Naproxen is added to therapy.
Nimesulide Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Nimesulide is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Nimesulide is added to therapy.
Oxprenolol Adverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Oxyphenbutazone Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Oxyphenbutazone is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Oxyphenbutazone is added to therapy.
Paracetamol Adverse Effect: A possible increased risk of hypoglycemia
Clinical Management: When Paracetamol is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Dose of Glipizide may need to be reduced when Paracetamol is added to therapy.
PhenacetinAdverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Phenacetin is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Phenacetin is added to therapy.
PhenylbutazoneAdverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When Phenylbutazone is coadministered with Glipizide , patients should be monitored more closely for hypoglycemia. Doses of Glipizide may need to be reduced when Phenylbutazone is added to therapy.
PindololAdverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Piroxicam Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
PropranololAdverse Effect: hypoglycemia, hyperglycemia, or hypertension
Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Ranitidine Adverse Effect: hypoglycemia
Clinical Management: Concurrent administration of glipizide and ranitidine is not recommended. If concurrent use cannot be avoided, monitor blood glucose for signs of hypoglycemia upon initiation of ranitidine. Reduce dose of glipizide as needed on the basis of serum blood glucose concentrations. Suggest switching to another anti-ulcer medication (eg, sucralfate) which has less potential to alter the pharmacokinetics of glipizide.
Selegiline Adverse Effect: excessive hypoglycemia, CNS depression, and seizures
Clinical Management: Blood glucose levels should be closely monitored when Selegiline is added or discontinued in a patient receiving Glipizide . Lower dose of Glipizide may be required with concomitant therapy.
SulphadiazineAdverse Effect: enhanced hypoglycemic effects
Clinical Management: Avoid the use of sulfonamide antibiotics in patients who are taking Glipizide . If concomitant use is necessary, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Tenoxicam Adverse Effect: a possible increased risk of hypoglycemia
Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
WarfarinAdverse Effect: an increased risk of hypoglycemia
Clinical Management: Patients receiving warfarin and glipizide concurrently should be monitored closely for hypoglycemia. Patients should receive instructions on the signs and symptoms of hypoglycemia and should be taught to perform blood glucose monitoring. |
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