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| Dosages: | | IV Infsn.:PANCREATIC CARCINOMA: 1000mg/m2 over 30min every 1 wk for upto 7 weeks, followed by 1 week rest. Prior to every dose monitor the Blood Counts:
Absolute Granuclocyte Count (G) & Platelet Count (P):G>1000 & P > 100000:Use 100% (of the dose).
G < 500-999 or P5000-99000:75% (of the dose).
G <5 or P<5000:With-hold Rx. Subsequently, 4 weeks (3 weeks Rx + 1 week rest) cycles may be administered with 25% dose increments (eg. 1250 followed by 1500mg/m2 every 1week cycles) subject to patient tolerance.
NON SMALL CELL LUNG CANCER:4 week cycles similar to the above.
NOTE:Reconstitute Inj with > 5ml NS for the 200mg powder or with 25ml NS for the 1mg powder. Concentrations > 40mg/ml might hamper drug dissolution. Store the Sol at 15-30 C & use within 24 hour. The drug can be given in the OPD. |
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