CMV retinitis
Infant, child > 3 month, adult: 5 mg/kg IV at constant rate over 1 h q 12 h × 14-21 day; then maintenance dose 5 mg/kg IV qd × 1 wk; or 6 mg/kg IV qd × 5 day. Or maintenance dose 1,000 mg PO or 500 mg PO q 3 h while awake, or 6 times/day. May reduce dosage if pt has neutropenia, anemia or thrombocytopenia.
Prevention of CMV in HIV
Infant, child: 5 mg/kg IV qd.
Adolescent, adult: 5-6 mg/kg IV qd × 5-7 day each wk or 1 gram PO tid with meals. Consider reducing dosage if pt has neutropenia, anemia, or thrombocytopenia.
Prevention of CMV in transplant pts
Adult: 5 mg/kg IV over 1 h q 12 h × 7-14 day, then maintenance dose 5 mg/kg/day × 1 wk or 6 mg/kg qd × 5 day. May reduce dosage if pt has neutropenia, anemia or thrombocytopenia.
Other CMV infection
Child, adult: 5 mg/kg IV over 1 h q 12 h × 14-21 day; or 2.5 mg/kg IV q 8 h × 14-21 day. May reduce dosage if pt has neutropenia, anemia, or thrombocytopenia. |