Aminosalicylic acid, chlorampheni-col, methotrexate, oral contraceptives, pyrimetha-mine, sulfasalazine, triamterene, trimethoprim: May act as antagonists to folic acid. Monitor child for desired effects.
Anticonvulsants (such as phenobarbital, pheny-toin): Increased anticonvulsant metabolism and decreased blood levels of anticonvufsants. Mon-itor child closely.
Phenytoin, primidone: Decreased serum folate levels; symptoms of folic acid deficiency in long-term therapy. Monitor child closely.
Pyrimethamine: May interfere with antimicrobial actions against toxoplasmosis. Monitor child for desired effects. |